Clinician-Supervised • Topical Peptide Cream • Shipped Nationwide
GHK-Cu Cream — Copper Peptide Skin Rejuvenation and Anti-Aging Therapy
Your skin has the ability to repair, regenerate, and rebuild itself. It does this every day — replacing old cells with new ones, producing collagen to maintain firmness, and repairing damage from UV exposure, pollution, and stress. But as you age, the signaling molecules that coordinate this repair process decline. Your skin doesn't lose the ability to regenerate. It loses the signal that tells it to.
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper peptide that acts as one of those critical signals. It tells your skin cells to produce more collagen, accelerate regeneration, reduce inflammation, and repair damage at the cellular level. GHK-Cu is one of the most researched peptides in skincare science, with decades of studies supporting its role in skin rejuvenation.
Reset IV's GHK-Cu Cream is a prescription-grade topical peptide cream shipped directly to your door as part of a clinician-supervised subscription. No injections. Just apply it to your skin and let the peptide do what your body's own signaling system used to do more effectively.
Price: $299/month — shipped to your door
What Is NAD+ and Why Does Your Body Need It?
GHK-Cu is a tripeptide — a short chain of three amino acids (glycine, histidine, lysine) bound to a copper ion. It's found naturally in your blood plasma, saliva, and urine. Your body produces GHK-Cu on its own, but like so many regenerative molecules, its levels decline significantly with age. By the time you're 60, your GHK-Cu levels may be less than a third of what they were at age 20.
What makes GHK-Cu remarkable is its ability to reprogram skin cells. When GHK-Cu is applied to your skin, it triggers a cascade of regenerative responses:
Stimulates collagen production: GHK-Cu signals your fibroblasts — the cells responsible for producing collagen and elastin — to increase production. More collagen means firmer, plumper skin with fewer wrinkles and fine lines.
Accelerates skin regeneration: The peptide boosts the production of new skin cells, speeding up the turnover process that keeps your complexion fresh and radiant. Old, damaged cells are replaced more quickly with healthy new ones.
Reduces inflammation: GHK-Cu has significant anti-inflammatory properties, helping calm irritated skin, reduce redness, and support healing. This makes it beneficial not just for aging but for overall skin health.
Supports wound healing: One of GHK-Cu's most well-studied properties is its ability to accelerate wound healing. It signals the skin to repair damage faster and more completely — a property that translates directly to repairing the micro-damage from UV exposure and environmental stress.
Acts as an antioxidant: The copper ion in GHK-Cu supports your skin's antioxidant defenses, helping neutralize the free radicals that damage collagen fibers and accelerate visible aging.
Improves elasticity and firmness: By stimulating both collagen and elastin production, GHK-Cu helps restore the structural proteins that give skin its bounce and firmness.
Unlike most skincare ingredients that work at the surface level, GHK-Cu works as a cellular signal — telling your skin's own cells to behave more like they did when you were younger. This is why researchers often describe it as a "reprogramming" peptide.
Benefits of GHK-Cu Cream
Reduces Fine Lines and Wrinkles
By stimulating collagen and elastin production, GHK-Cu helps fill in the fine lines and wrinkles that develop as these structural proteins decline with age. The effect is progressive — continued use leads to continued improvement as your skin produces more collagen over time.
Improves Skin Elasticity and Firmness
Sagging skin is caused by declining elastin and collagen. GHK-Cu addresses both, helping restore the bounce and firmness that makes skin look and feel younger. Many users notice their skin feels tighter and more resilient within weeks.
Boosts Skin Regeneration and Radiance
Faster cell turnover means fresher, more radiant skin. GHK-Cu accelerates the process of replacing old, dull surface cells with new, healthy ones. The result is a brighter, more even complexion with a natural glow.
Improves Skin Texture
Rough, uneven texture often results from slowed cell turnover and accumulated damage. GHK-Cu's regenerative signaling helps smooth and refine skin texture over time.
Reduces Redness and Inflammation
GHK-Cu's anti-inflammatory properties help calm irritated skin, reduce redness, and support a more even, balanced complexion. This makes it suitable for sensitive skin types as well.
Supports Skin Repair After Sun Damage
UV exposure is the primary external cause of visible skin aging. GHK-Cu supports the repair of UV-induced damage by stimulating the regenerative processes that rebuild damaged collagen and skin cells.
Strengthens the Skin Barrier
A healthy skin barrier protects against moisture loss, environmental irritants, and infection. GHK-Cu supports the production of the proteins and lipids that maintain a strong, functional skin barrier.
GHK-Cu vs. Retinol vs. Vitamin C Serum — How They Compare
Reset IV offers NAD+ IV therapy in 500mg and 1000mg doses, delivered via mobile service directly to your location. Each infusion includes a saline base for hydration and can be customized with add-on vitamins and supplements.
GHK-Cu Cream
Price: $-
How it works:
Signals skin cells to increase collagen production, accelerate regeneration, reduce inflammation, and repair damage at the cellular level.
Mechanism:
Peptide signaling — reprograms cell behavior.
Irritation:
Generally well-tolerated. Anti-inflammatory properties may actually calm irritation.
Best for: Fine lines, wrinkles, elasticity loss, overall skin rejuvenation, post-UV repair, sensitive skin.
Retinol / Retinoids
Price: $-
How it works:
Increase cell turnover speed by binding to retinoid receptors. Also support collagen production.
Mechanism:
Receptor-mediated — forces faster cell turnover.
Irritation:
Can cause significant dryness, peeling, and irritation, especially during the first weeks. Not suitable for all skin types.
Best for: Acne, hyperpigmentation, deep wrinkles. Powerful but requires tolerance buildup.
Vitamin C Serum
Price: $-
How it works:
Acts as an antioxidant, supports collagen synthesis, and brightens complexion.
Mechanism:
Antioxidant protection and cofactor for collagen production.
Irritation:
Generally mild, though some forms can sting on sensitive skin. Unstable — degrades quickly when exposed to air and light.
Best for: Brightening, evening skin tone, antioxidant protection. Less structural than GHK-Cu or retinoids.
Many skincare experts layer these ingredients because they work through different mechanisms. GHK-Cu is the signaling peptide that tells cells what to do. Retinol speeds up the process. Vitamin C provides antioxidant protection. Consult your medical provider about how GHK-Cu fits into your existing routine.
For clients who also want internal antioxidant support, Reset IV's Skin Rejuvenation IV delivers Vitamin C and Glutathione directly into your bloodstream alongside GHK-Cu's topical benefits.
How to Use GHK-Cu Cream
Application
Apply a thin layer to clean, dry skin. Can be used on face, neck, décolletage, and backs of hands — anywhere you want rejuvenation.
Frequency
Once or twice daily, as directed by your medical provider. Many clients apply in the evening as part of their nighttime routine.
Layering
GHK-Cu Cream can be layered with other skincare products. Apply after cleansing and before heavier moisturizers or SPF. Consult your provider about combining with retinoids or other active ingredients.
Storage
Store as directed in the instructions included with your cream.
Sun protection
Always use sunscreen during the day when using active skincare ingredients. UV exposure is the primary external cause of the damage GHK-Cu helps repair.
No injections required
Unlike other peptide therapies in Reset IV's lineup, GHK-Cu is a topical cream. Just apply it — no needles, no preparation.
How It Works
Step 1
Virtual Consultation
Schedule an online consultation with one of our medical providers. They'll review your skin concerns, health history, and goals to confirm GHK-Cu Cream is right for you.
Step 2
Shipped to Your Door
Once approved, your GHK-Cu Cream ships directly to your home. Expect delivery within approximately one week.
Step 3
Apply Daily
Apply the cream to clean skin as directed — typically once or twice daily to the face, neck, and any areas of concern. No injections, no preparation. Just smooth it on as part of your morning or evening skincare routine.
Step 4
Monthly Refills, Progressive Results
Your subscription ensures a continuous supply with automatic monthly shipments. Results build progressively — most users notice visible improvements in skin texture and radiance within the first few weeks, with collagen-related improvements (firmness, wrinkle reduction) developing over 2 to 3 months of consistent use.
What to Expect — Results Timeline
Weeks 1–2
Skin may feel smoother and more hydrated. Some users notice a subtle glow as cell turnover begins to accelerate. Anti-inflammatory effects may reduce redness.
Weeks 3–4
Texture improvements become more noticeable. Skin looks fresher and more even. Fine lines may begin to soften.
Months 2–3
Collagen production builds progressively. Wrinkle reduction becomes more visible. Skin feels firmer and more elastic. This is where most users describe significant visible improvement.
Months 4+
Continued improvement in firmness, elasticity, and overall skin quality. Results compound with consistent daily use. Many long-term users report their skin looks and behaves years younger.
GHK-Cu is a progressive therapy. It works by changing how your skin cells behave over time, not by providing an instant surface-level effect. Clients who use it consistently see the strongest results.
Who Is GHK-Cu Cream For?
- People concerned about fine lines and wrinkles: GHK-Cu stimulates the collagen production that fills in lines and restores youthful smoothness.
- People noticing sagging or loss of firmness: Declining collagen and elastin cause skin to lose its bounce. GHK-Cu signals your cells to produce more of both.
- People with dull, uneven skin: Accelerated cell regeneration replaces tired, damaged surface cells with fresh, radiant ones.
-
- People who want a science-backed anti-aging approach: GHK-Cu has decades of published research supporting its role in skin rejuvenation. This isn't a marketing-driven ingredient — it's a well-studied peptide.
- People with sensitive skin: Unlike retinoids, GHK-Cu is anti-inflammatory and generally well-tolerated. It may actually calm irritation rather than cause it.
- People recovering from sun damage: GHK-Cu supports the repair of UV-induced damage by stimulating the regenerative processes your skin needs to rebuild.
- People who prefer topical over injectable: GHK-Cu is a cream — no needles required. Ideal for people who want peptide-level results without injections.
-
- People who want to complement their existing routine: GHK-Cu works through a unique signaling mechanism that complements retinol, vitamin C, and other active ingredients.
Why Choose Reset IV for GHK-Cu Cream
Clinician-Supervised
Every subscription begins with a virtual consultation. This is a prescription-grade peptide cream, not an over-the-counter product.
Shipped to Your Door
No dermatologist appointments after enrollment. Your cream arrives at home and refills ship automatically.
$299/month
Straightforward monthly pricing with no hidden fees. Consultation included.
No Injections
Unlike Sermorelin and PT-141, GHK-Cu is a topical cream. Just apply it to your skin as part of your daily routine.
Prescription-Grade Formulation
Higher concentration and purity than over-the-counter copper peptide products. Clinician-supervised for safety and efficacy.
Complements Reset IV's Beauty IV Treatments
Pair with the Skin Rejuvenation IV ($269) for internal Vitamin C and Glutathione, or the Hair, Skin & Nail Strengthener ($329) for Biotin and antioxidant support.
Progressive, Long-Term Results
GHK-Cu builds results over time by changing how your skin cells behave. Consistent use compounds the benefits.
FAQ's
FAQ
What is GHK-Cu?
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper peptide found in your blood plasma. It signals skin cells to produce more collagen, accelerate regeneration, reduce inflammation, and repair damage. It's one of the most well-researched peptides in skincare science. Reset IV offers it as a prescription-grade topical cream for $299/month.
How does GHK-Cu cream work?
GHK-Cu acts as a signaling peptide. When applied to your skin, it tells fibroblasts to increase collagen and elastin production, accelerates cell turnover for fresher skin, reduces inflammation and redness, and supports repair of UV and environmental damage. It essentially reprograms your skin cells to behave more like they did when you were younger.
Is this a cream or an injection?
GHK-Cu is a topical cream — no injections required. You apply it to clean skin once or twice daily as part of your regular skincare routine. It's the only peptide in Reset IV's lineup that doesn't involve needles.
How is this different from over-the-counter copper peptide products?
Reset IV's GHK-Cu Cream is a prescription-grade formulation with higher concentration and purity than consumer products found in stores. A clinician reviews your skin concerns and health history before prescribing. Higher-grade formulations deliver more peptide to your skin cells for stronger results.
How much does it cost?
$299/month. Includes virtual consultation and monthly cream shipped to your door. No hidden fees.
When will I see results?
Smoother texture and subtle glow often appear within the first 2 weeks. More noticeable improvements in wrinkles, firmness, and elasticity typically develop over 2 to 3 months. Results build progressively with daily use.
Can I use GHK-Cu with retinol or vitamin C?
GHK-Cu works through a different mechanism than retinol or vitamin C, so they can complement each other. Consult your medical provider about how to layer them in your routine. Many skincare experts recommend using multiple active ingredients that work through different pathways.
Is GHK-Cu safe for sensitive skin?
GHK-Cu is generally well-tolerated and has anti-inflammatory properties that may actually help calm irritated skin. Unlike retinoids, it's not known for causing dryness, peeling, or irritation. However, always patch-test new products and consult your provider.
Do I need a consultation?
Yes. A virtual consultation with a medical provider is required to confirm GHK-Cu Cream is appropriate for your skin concerns and health situation. The consultation is included in your subscription.
How quickly will my cream arrive?
Most orders ship within approximately one week of your virtual consultation. Monthly refills ship automatically.
Can I combine this with Reset IV's beauty IVs?
Absolutely. GHK-Cu works topically on the outside while the Skin Rejuvenation IV ($269) delivers Vitamin C and Glutathione internally, and the Hair, Skin & Nail Strengthener ($329) provides Biotin and antioxidant support from the inside. The combination of topical peptide and IV antioxidants provides comprehensive inside-out skin care.
How do I get started?
Visit resetiv.com or call/text 1-844-387-4870. Schedule a virtual consultation, and once approved, your GHK-Cu Cream ships to your door.
Related Products and Treatments
Skin Rejuvenation IV
Internal antioxidant support. Vitamin C + Glutathione delivered into your bloodstream. Pair with GHK-Cu for inside-out skin care. $269.
Peptide Therapy Hub
Explore all Reset IV peptide therapies including Sermorelin and PT-141.
Sermorelin Peptide Therapy
Growth hormone support for lean muscle, fat loss, and vitality. $299/month.
Hair, Skin & Nail Strengthener IV
Biotin + Glutathione Push + Vitamin C Super Dose for structural beauty support. $329.
Your Skin Still Knows How to Regenerate. Give It the Signal.
GHK-Cu is the copper peptide that tells your skin cells to produce more collagen, regenerate faster, and repair damage at the cellular level. It's the signal your skin has been missing. Prescription-grade, clinician-supervised, shipped to your door. No injections — just apply and let the peptide work. $299/month.
Medical Disclaimer
Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. A virtual consultation with a medical provider is required before any prescription is issued. These services have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. Always consult your physician or dermatologist before beginning any skincare treatment or therapy program. Any designations or references to therapies are for marketing purposes only and do not represent actual products. If you are experiencing a medical emergency, call 911.
